The crash happened by the exit for Exit: PA 741 - MILLERSVILLE/ROHRERSTOWN in East Hempfield Township at 10:46 a.m., authorities say.
The box truck involved was supposedly hit in the side and split open, spilled its unknown contents unto the roadway, dispatchers say.
RT 30 east remained closed two hours later and PennDOT officials are sure when the roadway will be cleared and reopened.
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